Association Between Delivery Method and Offspring's Risk of Inflammatory Bowel Disease: A Comprehensive Systematic Review and Meta-Analysis - Takeaways - MDSpire

Association Between Delivery Method and Offspring's Risk of Inflammatory Bowel Disease: A Comprehensive Systematic Review and Meta-Analysis

  • By

  • Hana Taha

  • Mohammad Al-Shalalfeh

  • Almothana Khalil

  • Yumna Khasawneh

  • Aseel Abu Ata

  • Hala AbuEin

  • Ahmad Issa

  • Taher Alhawamdeh

  • Mishkah BaniMustafa

  • Mohammed Qussay Al-Sabbagh

  • Linus Jönsson

  • April 8, 2026

  • 0 min

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  • 1

    This systematic review and meta-analysis evaluated the association between cesarean section and inflammatory bowel disease risk in offspring.

  • 2

    Twenty-two studies with over 13 million births were included, showing no significant association between cesarean section and IBD, Crohn's disease, or ulcerative colitis.

  • 3

    Unadjusted analyses indicated an inverse association between cesarean section and ulcerative colitis, but adjusted analyses showed no significant relationships.

  • 4

    Regional variations were noted, with cesarean section linked to reduced IBD risk in some countries and increased risk in others.

  • 5

    The findings provide reassurance for clinical counseling regarding cesarean delivery and its long-term implications for inflammatory bowel disease risk.

Original Source(s)

Association Between Delivery Method and Offspring's Risk of Inflammatory Bowel Disease: A Comprehensive Systematic Review and Meta-Analysis

  • by Hana Taha, Mohammad Al-Shalalfeh, Almothana Khalil, Yumna Khasawneh, Aseel Abu Ata, Hala AbuEin, Ahmad Issa, Taher Alhawamdeh, Mishkah BaniMustafa, Mohammed Qussay Al-Sabbagh, Linus Jönsson

  • April 8, 2026

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