Anatomical site and histological subtype as determinants of Breslow thickness and high-risk features in surgically managed cutaneous melanoma at Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa - Takeaways - MDSpire
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Influence of Anatomical Location and Histological Type on Breslow Thickness and High-Risk Characteristics in Surgically Treated Cutaneous Melanoma at Charlotte Maxeke Johannesburg Academic Hospital, South Africa

  • By

  • Rahmiz Thomas

  • Yazeerah Bhana

  • Marina Butoi

  • Inam Madikizela

  • Sibusiso Mahlangu

  • Zoë Malan

  • Thato Mpapa

  • Ethan Naidoo

  • Wilhelm Hansen

  • Thifhelimbilu Emmanuel Luvhengo

  • Nosisa Thabile Sishuba

  • August 25, 2026

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  • 1

    Breslow thickness is crucial for staging cutaneous melanoma and influences surgical management decisions.

  • 2

    Acral and lower-limb melanomas are associated with greater Breslow thickness compared to trunk lesions.

  • 3

    Acral lentiginous, nodular, and lentigo maligna melanomas present with greater Breslow thickness than superficial spreading melanoma.

  • 4

    Ulceration correlates with increased Breslow thickness, with an odds ratio of 2.90.

  • 5

    No independent associations were found between Breslow thickness or ulceration and nodal positivity.

Original Source(s)

Anatomical site and histological subtype as determinants of Breslow thickness and high-risk features in surgically managed cutaneous melanoma at Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa

  • by Rahmiz Thomas, Yazeerah Bhana, Marina Butoi, Inam Madikizela, Sibusiso Mahlangu, Zoë Malan, Thato Mpapa, Ethan Naidoo, Wilhelm Hansen, Thifhelimbilu Emmanuel Luvhengo, Nosisa Thabile Sishuba

  • August 25, 2026

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