Soluble fms-like tyrosine kinase-1 and peripartum cardiomyopathy: an exploratory meta-analysis of association and diagnostic performance - Takeaways - MDSpire

Soluble fms-like tyrosine kinase-1 and peripartum cardiomyopathy: an exploratory meta-analysis of association and diagnostic performance

  • By

  • Triwedya Indra Dewi

  • William Kamarullah

  • Hawani Sasmaya Prameswari

  • Chaerul Achmad

  • Ruswana Anwar

  • Delvac Oceandy

  • Firman Fuad Wirakusumah

  • June 8, 2026

  • 0 min

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  • 1

    Peripartum cardiomyopathy (PPCM) is a rare but serious heart failure condition occurring late in pregnancy or postpartum.

  • 2

    Elevated soluble fms-like tyrosine kinase-1 (sFlt-1) levels are associated with increased risk of PPCM, with a pooled odds ratio of 1.79.

  • 3

    The diagnostic performance of sFlt-1 for PPCM is modest, with sensitivity at 72% and specificity at 57%.

  • 4

    The association between sFlt-1 and PPCM is stronger in women with pre-eclampsia, showing an odds ratio of 2.11.

  • 5

    Findings suggest that sFlt-1 may not be suitable for antepartum screening, necessitating larger prospective studies for clinical application.

Original Source(s)

Soluble fms-like tyrosine kinase-1 and peripartum cardiomyopathy: an exploratory meta-analysis of association and diagnostic performance

  • by Triwedya Indra Dewi, William Kamarullah, Hawani Sasmaya Prameswari, Chaerul Achmad, Ruswana Anwar, Delvac Oceandy, Firman Fuad Wirakusumah

  • June 8, 2026

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