Recurrent meningioma treated with boron neutron capture therapy: a feasibility study with dosimetric and clinical correlates

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Meningiomas are the most common primary brain tumors, with treatment strategies needing to balance tumor control and neurological impairment.
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Surgical resection is the primary treatment for symptomatic meningiomas, but complete removal is often complicated by tumor location and grade.
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Boron neutron capture therapy (BNCT) offers a promising approach for recurrent meningiomas, targeting tumor cells while sparing healthy tissue.
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This study analyzed 13 patients treated with salvage BNCT, focusing on treatment response and tumor control after initial recurrence.
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Tumor response was evaluated using MRI and RANO criteria, with progression-free survival defined from BNCT to disease progression or last follow-up.

Journal Of Neuro-Oncology

by Tien-Li Lan, Chun-Fu Lin, Yi-Yen Lee, Feng-Chi Chang, Shih-Chieh Lin, Fong-In Chou, Jinn-Jer Peir, Po-Shen Pan, Jen-Kun Chen, Lu-Han Lai, Hiroki Tanaka, Shih-Ming Hsu, Yi-Wei Chen
July 31, 2025

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