The prognostic value of systemic inflammatory response index (SIRI) in acute coronary syndrome patients treated with primary percutaneous coronary intervention: a meta-analysis and systematic review - Takeaways - MDSpire
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Evaluating the Prognostic Significance of the Systemic Inflammatory Response Index (SIRI) in Patients with Acute Coronary Syndrome Undergoing Primary Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis

  • By

  • Chenming Hu

  • Qianling Ye

  • Shunjie You

  • Si Li

  • Christopher Dostal

  • Matthias Ernst

  • Francesco Paneni

  • Peter Pokreisz

  • Gabor Tamas Szabo

  • Attila Kiss

  • Bruno K. Podesser

  • March 16, 2026

Share

  • 1

    Acute coronary syndromes are a leading cause of morbidity, with significant residual risk of adverse cardiovascular events post-percutaneous coronary intervention.

  • 2

    The systemic inflammatory response index (SIRI) is a novel biomarker reflecting the inflammatory and immune response balance in patients with coronary artery disease.

  • 3

    Elevated SIRI levels indicate significant pro-inflammatory reactions, which can predict prognosis in patients with coronary artery disease after PCI.

  • 4

    This systematic review and meta-analysis aim to assess the prognostic significance of SIRI in patients with acute coronary syndrome undergoing PCI.

  • 5

    A definitive consensus on the clinical utility of SIRI in predicting mortality and major adverse cardiovascular events post-PCI remains lacking.

Original Source(s)

The prognostic value of systemic inflammatory response index (SIRI) in acute coronary syndrome patients treated with primary percutaneous coronary intervention: a meta-analysis and systematic review

  • by Chenming Hu, Qianling Ye, Shunjie You, Si Li, Christopher Dostal, Matthias Ernst, Francesco Paneni, Peter Pokreisz, Gabor Tamas Szabo, Attila Kiss, Bruno K. Podesser

  • March 16, 2026

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