The prognostic value of systemic inflammatory response index (SIRI) in acute coronary syndrome patients treated with primary percutaneous coronary intervention: a meta-analysis and systematic review

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Acute coronary syndromes are a leading cause of morbidity, with significant residual risk of adverse cardiovascular events post-percutaneous coronary intervention.
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The systemic inflammatory response index (SIRI) is a novel biomarker reflecting the inflammatory and immune response balance in patients with coronary artery disease.
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Elevated SIRI levels indicate significant pro-inflammatory reactions, which can predict prognosis in patients with coronary artery disease after PCI.
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This systematic review and meta-analysis aim to assess the prognostic significance of SIRI in patients with acute coronary syndrome undergoing PCI.
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A definitive consensus on the clinical utility of SIRI in predicting mortality and major adverse cardiovascular events post-PCI remains lacking.

Clinical Research In Cardiology (Springer)

by Chenming Hu, Qianling Ye, Shunjie You, Si Li, Christopher Dostal, Matthias Ernst, Francesco Paneni, Peter Pokreisz, Gabor Tamas Szabo, Attila Kiss, Bruno K. Podesser
March 16, 2026

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