Association between clinically relevant antibiotic-resistant biliary colonization and liver-specific complications following perihilar cholangiocarcinoma resection

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Surgery is crucial for treating perihilar cholangiocarcinoma, with postoperative morbidity at 65% and mortality at 14%.
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The study evaluates the resistance profile of biliary bacteria and its impact on liver-specific complications, particularly bile leaks.
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Patients with antibiotic-resistant bacteria were compared to non-resistant patients to analyze correlations with severe bile leakage.
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Microorganisms were detected in 89.4% of intraoperative bile swabs, with 67.3% positive for Gram-positive and 52.9% for Gram-negative bacteria.
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The study included 118 patients, with a median age of 67 years, and most underwent extended hepatectomy.

Langenbecks Archives Of Surgery

by Faruk Koca, Hanan El Youzouri, Svenja Sliwinski, Konstantin Uttinger, Ursula Pession, Ekaterina Petrova, Dirk Walter, Michael Hogardt, Volkhard A. J. Kempf, Andreas A. Schnitzbauer, Armin Wiegering, Tamás Benkö
July 17, 2026

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