Plasma phosphorylated tau217 strongly associates with memory deficits in the Alzheimer’s disease spectrum - Takeaways - MDSpire

Plasma phosphorylated tau217 strongly associates with memory deficits in the Alzheimer’s disease spectrum

  • By

  • Jaime Fernández Arias

  • Wagner S Brum

  • Gemma Salvadó

  • Joseph Therriault

  • Stijn Servaes

  • Yi-Ting Wang

  • Etienne Aumont

  • Nesrine Rahmouni

  • Arthur C Macedo

  • Kely Monica Quispialaya

  • Seyyed Ali Hosseini

  • Peter Kunach

  • Wan Lu Jia

  • Tevy Chan

  • Lydia Trudel

  • Brandon Hall

  • Yanseng Zheng

  • Sejal Mohapatra

  • Sulantha S Mathotaarachchi

  • Paolo Vitali

  • Cécile Tissot

  • Gleb Bezgin

  • Yasser Iturria-Medina

  • Nicholas J Ashton

  • Andréa Lessa Benedet

  • Thomas K Karikari

  • Gallen Triana-Baltzer

  • Jesse M Klostranec

  • Hartmuth C Kolb

  • Eduardo R Zimmer

  • Shorena Janelidze

  • Niklas Mattsson-Carlgren

  • Erik Stomrud

  • Sebastian Palmqvist

  • Henrik Zetterberg

  • Kaj Blennow

  • Tharick Pascoal

  • Maxime Montembeault

  • Oskar Hansson

  • Pedro Rosa-Neto

  • January 29, 2025

  • 0 min

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  • 1

    Plasma phosphorylated tau217 (p-tau217) is a promising biomarker for identifying cognitive impairments in Alzheimer's disease.

  • 2

    In a study, p-tau217 showed stronger associations with memory scores compared to p-tau181 and p-tau231.

  • 3

    Plasma p-tau217 outperformed other biomarkers in identifying memory and executive function impairments.

  • 4

    Cognitively impaired individuals with amyloid-β positivity exhibited significant cognitive deficits across all biomarkers.

  • 5

    Memory deficits were observed in individuals with positive amyloid and p-tau but negative tau PET scans.

Original Source(s)

Plasma phosphorylated tau217 strongly associates with memory deficits in the Alzheimer’s disease spectrum

  • by Jaime Fernández Arias, Wagner S Brum, Gemma Salvadó, Joseph Therriault, Stijn Servaes, Yi-Ting Wang, Etienne Aumont, Nesrine Rahmouni, Arthur C Macedo, Kely Monica Quispialaya, Seyyed Ali Hosseini, Peter Kunach, Wan Lu Jia, Tevy Chan, Lydia Trudel, Brandon Hall, Yanseng Zheng, Sejal Mohapatra, Sulantha S Mathotaarachchi, Paolo Vitali, Cécile Tissot, Gleb Bezgin, Yasser Iturria-Medina, Nicholas J Ashton, Andréa Lessa Benedet, Thomas K Karikari, Gallen Triana-Baltzer, Jesse M Klostranec, Hartmuth C Kolb, Eduardo R Zimmer, Shorena Janelidze, Niklas Mattsson-Carlgren, Erik Stomrud, Sebastian Palmqvist, Henrik Zetterberg, Kaj Blennow, Tharick Pascoal, Maxime Montembeault, Oskar Hansson, Pedro Rosa-Neto

  • January 29, 2025

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