Inflammatory indexes as prognostic biomarkers in advanced triple negative breast cancer patients - Takeaways - MDSpire

Inflammatory indexes as prognostic biomarkers in advanced triple negative breast cancer patients

  • By

  • Caterina Gianni

  • Emanuela Scarpi

  • Eva Blondeaux

  • Michela Palleschi

  • Filippo Merloni

  • Lorenzo Gasperoni

  • Fabio Puglisi

  • Elena Collovà

  • Palma Pugliese

  • Francesco Cognetti

  • Irene Giannubilo

  • Tommaso Ruelle

  • Lucia Del Mastro

  • Claudia Bighin

  • Antonino Musolino

  • Ugo De Giorgi

  • July 15, 2026

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  • 1

    The study analyzed the prognostic value of inflammatory markers in 114 patients with metastatic triple-negative breast cancer (TNBC).

  • 2

    High inflammatory scores, particularly NLR, MLR, PLR, and SII, were significantly associated with lower progression-free survival (PFS) and overall survival (OS).

  • 3

    Median PFS was 8.6 months and median OS was 17.7 months for the overall patient population at a median follow-up of 28 months.

  • 4

    In multivariable analysis, the number of metastatic sites, NLR, SII, and MLR were significant predictors of overall survival.

  • 5

    The findings suggest that inflammatory ratios may serve as feasible prognostic biomarkers in metastatic TNBC, pending validation in larger studies.

Original Source(s)

Inflammatory indexes as prognostic biomarkers in advanced triple negative breast cancer patients

  • by Caterina Gianni, Emanuela Scarpi, Eva Blondeaux, Michela Palleschi, Filippo Merloni, Lorenzo Gasperoni, Fabio Puglisi, Elena Collovà, Palma Pugliese, Francesco Cognetti, Irene Giannubilo, Tommaso Ruelle, Lucia Del Mastro, Claudia Bighin, Antonino Musolino, Ugo De Giorgi

  • July 15, 2026

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