Impact of Polysaccharides from Traditional Chinese Medicine on Rheumatoid Arthritis via Gut Microbiota Alteration: A Systematic Review of Animal Studies - Takeaways - MDSpire

Impact of Polysaccharides from Traditional Chinese Medicine on Rheumatoid Arthritis via Gut Microbiota Alteration: A Systematic Review of Animal Studies

  • By

  • Suhai Qian

  • Yibo Jin

  • Chao Hu

  • Yuanyuan Luo

  • Runyu Chang

  • Jingyi Wu

  • Xinghong Ding

  • April 23, 2026

  • 0 min

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  • 1

    Traditional Chinese medicine polysaccharides (TCMPs) show promise as low-toxicity treatments for rheumatoid arthritis (RA) by modulating gut microbiota.

  • 2

    TCMPs significantly alleviate RA symptoms, improve bone quality, and induce beneficial changes in gut microbiota composition.

  • 3

    Nine phyla and 65 genera of gut microbiota were altered by TCMPs, with notable increases in beneficial taxa like Lactobacillus and Bifidobacterium.

  • 4

    The modulation of gut microbiota by TCMPs correlates with reduced pro-inflammatory cytokines and enhanced production of short-chain fatty acids.

  • 5

    Future research should focus on improving study quality and integrating multi-omics approaches to better understand TCMPs' therapeutic potential for RA.

Original Source(s)

Impact of Polysaccharides from Traditional Chinese Medicine on Rheumatoid Arthritis via Gut Microbiota Alteration: A Systematic Review of Animal Studies

  • by Suhai Qian, Yibo Jin, Chao Hu, Yuanyuan Luo, Runyu Chang, Jingyi Wu, Xinghong Ding

  • April 23, 2026

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