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1
INSM1 demonstrated 96.3% sensitivity for the SmCC compartment in mixed renal pelvic UC/SmCC, outperforming traditional markers like synaptophysin and chromogranin A.
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2
All paired UC components were found to be INSM1-negative, indicating its specificity for the SmCC component in mixed tumors.
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3
The median Ki-67 index was significantly higher in SmCC compared to UC, suggesting a difference in proliferation rates between the two components.
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4
Advanced pT stage, nodal metastasis, predominant SmCC burden, and higher INSM1 H-score were associated with poorer overall survival in the cohort.
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5
The study highlights the potential of INSM1 as a reliable marker for identifying neuroendocrine differentiation in mixed renal pelvic carcinomas.
