Challenges and Enablers in Platform Trial Methodologies

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Platform trials allow for simultaneous evaluation of multiple interventions, enhancing efficiency compared to traditional randomized clinical trials.
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The initiation of platform trials doubled at the start of the COVID-19 pandemic, highlighting their growing importance in clinical research.
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Challenges in platform trials include operational complexity, resource capacity prediction, funding acquisition, and engagement with pharmaceutical companies.
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A survey was conducted to gather insights from platform trial teams on barriers and facilitators, aiming to improve clinical trial infrastructure.
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The research team included experts in clinical research methods and bioethics, ensuring a comprehensive approach to understanding platform trials.

Jama Network Open

by Stuart McLennan, Alexandra Griessbach, Sharon Love, Christof Manuel Schönenberger, Alain Amstutz, Lucille Sebastian, Dominique Costagliola, Inge Christoffer Olsen, Corina Silvia Rueegg, Matthew R. Sydes, Matthias Briel, Benjamin Speich
April 2, 2026

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