Rapid antimicrobial susceptibility testing did not improve 30-day clinical outcomes compared to standard testing in gram-negative bloodstream infections.
2
Patients receiving rapid testing experienced faster antibiotic modification, with median times of 22 hours versus 36 hours for standard testing.
3
The proportion of patients receiving effective therapy within 24 hours was higher in the rapid testing group at 84% compared to 75% in the standard group.
4
Subgroup analysis indicated rapid testing was particularly beneficial for patients with carbapenem-resistant infections, showing faster effective therapy.
5
The trial's limitations included its open-label design and variability in local antibiotic availability, which may affect generalizability.
