Trajectory models of serum creatinine and 28-day mortality in critically ill patients with sepsis complicated by type 2 diabetes mellitus: a cohort study - Takeaways - MDSpire

Trajectory models of serum creatinine and 28-day mortality in critically ill patients with sepsis complicated by type 2 diabetes mellitus: a cohort study

  • By

  • Shu Yang

  • Lianzheng Ma

  • Jinfang Zeng

  • Yiwen Guo

  • Chunyi Wu

  • Xiao Zhang

  • Minmin Zhu

  • June 23, 2026

  • 0 min

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  • 1

    The study analyzed serum creatinine trends and 28-day mortality risk in critically ill patients with sepsis and type 2 diabetes mellitus.

  • 2

    A total of 1909 patients were included, with a 28-day all-cause mortality rate of approximately 23.0%.

  • 3

    Three serum creatinine trajectory patterns were identified: low-stable, moderate-increasing, and persistently high.

  • 4

    Patients with moderate-increasing and persistently high creatinine trajectories had significantly elevated mortality risk.

  • 5

    Continuous renal replacement therapy may partially mediate the association between elevated creatinine levels and mortality risk.

Original Source(s)

Trajectory models of serum creatinine and 28-day mortality in critically ill patients with sepsis complicated by type 2 diabetes mellitus: a cohort study

  • by Shu Yang, Lianzheng Ma, Jinfang Zeng, Yiwen Guo, Chunyi Wu, Xiao Zhang, Minmin Zhu

  • June 23, 2026

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