Physical factor therapies for insomnia: a narrative review of mechanisms, clinical evidence, and phenotype-guided applications - Takeaways - MDSpire

Physical factor therapies for insomnia: a narrative review of mechanisms, clinical evidence, and phenotype-guided applications

  • By

  • Shuhui Li

  • Qiubai Long

  • Dongfeng Huang

  • Yurong Mao

  • June 22, 2026

  • 0 min

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  • 1

    Pharmacological treatments for insomnia are limited by risks of tolerance, dependence, and daytime effects, prompting interest in non-pharmacological interventions.

  • 2

    The review examines five physical factor therapies for insomnia: auditory stimulation, phototherapy, thermotherapy, electrical stimulation, and magnetic stimulation.

  • 3

    Physical factor therapies target insomnia's mechanisms through peripheral sensory modulation, central neuromodulation, or systemic autonomic regulation.

  • 4

    Clinical evidence for these therapies is heterogeneous, with varying efficacy, safety, and limitations noted across randomized controlled trials and meta-analyses.

  • 5

    Future research should focus on larger sham-controlled trials, standardized protocols, and biomarker-guided stratification for insomnia treatments.

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