Association of Daily Body Temperature, White Blood Cell Count, and C-reactive Protein With Mortality and Persistent Bacteremia in Patients With Staphylococcus Aureus Bacteremia: A Post Hoc Analysis of the CAMERA2 Randomized Clinical Trial - Takeaways - MDSpire

Association of Daily Body Temperature, White Blood Cell Count, and C-reactive Protein With Mortality and Persistent Bacteremia in Patients With Staphylococcus Aureus Bacteremia: A Post Hoc Analysis of the CAMERA2 Randomized Clinical Trial

  • By

  • Sean W X Ong

  • Nick Daneman

  • Joshua S Davis

  • Steven Y C Tong

  • for the Combination Antibiotics for MEthicillin Resistant Staphylococcus aureus (CAMERA2) Study Group

  • David C Lye

  • Dafna Yahav

  • Archana Sud

  • J Owen Robinson

  • Jane Nelson

  • Sophia Archuleta

  • Matthew A Roberts

  • Alan Cass

  • David L Paterson

  • Hong Foo

  • Mical Paul

  • Stephen D Guy

  • Adrian R Tramontana

  • Genevieve B Walls

  • Stephen McBride

  • Narin Bak

  • Niladri Ghosh

  • Benjamin A Rogers

  • Anna P Ralph

  • Jane Davies

  • Patricia E Ferguson

  • Ravindra Dotel

  • Genevieve L McKew

  • Timothy J Gray

  • Natasha E Holmes

  • Simon Smith

  • Morgyn S Warner

  • Shirin Kalimuddin

  • Barnaby E Young

  • Naomi Runnegar

  • David N Andresen

  • Nicholas A Anagnostou

  • Mark D Chatfield

  • Allen C Cheng

  • Vance G Fowler

  • Benjamin P Howden

  • Niamh Meagher

  • David J Price

  • Sebastiaan J van Hal

  • Matthew V N O Sullivan

  • January 30, 2025

  • 0 min

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  • 1

    Daily body temperature, white blood cell levels, and C-reactive protein were analyzed for their prognostic relevance in Staphylococcus aureus bacteremia.

  • 2

    Fever (body temperature ≥38.0 °C) was linked to increased 90-day mortality, particularly from day 4 onwards.

  • 3

    Persistent fever after 72 hours indicated higher mortality risk, supporting its use in classifying patients as high-risk.

  • 4

    C-reactive protein and abnormal white blood cell counts did not show consistent associations with mortality in this analysis.

  • 5

    The study suggests reevaluating risk stratification algorithms for Staphylococcus aureus bacteremia based on readily available clinical parameters.

Original Source(s)

Association of Daily Body Temperature, White Blood Cell Count, and C-reactive Protein With Mortality and Persistent Bacteremia in Patients With Staphylococcus Aureus Bacteremia: A Post Hoc Analysis of the CAMERA2 Randomized Clinical Trial

  • by Sean W X Ong, Nick Daneman, Joshua S Davis, Steven Y C Tong, for the Combination Antibiotics for MEthicillin Resistant Staphylococcus aureus (CAMERA2) Study Group, David C Lye, Dafna Yahav, Archana Sud, J Owen Robinson, Jane Nelson, Sophia Archuleta, Matthew A Roberts, Alan Cass, David L Paterson, Hong Foo, Mical Paul, Stephen D Guy, Adrian R Tramontana, Genevieve B Walls, Stephen McBride, Narin Bak, Niladri Ghosh, Benjamin A Rogers, Anna P Ralph, Jane Davies, Patricia E Ferguson, Ravindra Dotel, Genevieve L McKew, Timothy J Gray, Natasha E Holmes, Simon Smith, Morgyn S Warner, Shirin Kalimuddin, Barnaby E Young, Naomi Runnegar, David N Andresen, Nicholas A Anagnostou, Mark D Chatfield, Allen C Cheng, Vance G Fowler, Benjamin P Howden, Niamh Meagher, David J Price, Sebastiaan J van Hal, Matthew V N O Sullivan

  • January 30, 2025

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