Xiangdan Injection Mitigates Cardiac Injury in Experimental Sepsis through Inflammatory Suppression and Mitochondrial Protection - Takeaways - MDSpire

Xiangdan Injection Mitigates Cardiac Injury in Experimental Sepsis through Inflammatory Suppression and Mitochondrial Protection

  • By

  • Xu, Jingyu

  • March 23, 2026

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  • 1

    Xiangdan injection reduces cardiac damage in experimental sepsis by modulating inflammation and protecting mitochondria.

  • 2

    In untreated sepsis, survival rates were significantly low, with 60% for Gram-positive and 70% for Gram-negative models.

  • 3

    Xiangdan injection improved survival rates in a dose-dependent manner, achieving 100% survival at 5.0 mL/kg.

  • 4

    Xiangdan injection significantly reduced serum inflammatory cytokines and cardiac injury biomarkers compared to untreated sepsis.

  • 5

    Mitochondrial ultrastructural damage was markedly reduced by Xiangdan treatment, indicating preserved mitochondrial integrity.

Original Source(s)

Xiangdan Injection Mitigates Cardiac Injury in Experimental Sepsis through Inflammatory Suppression and Mitochondrial Protection

  • by Xu, Jingyu

  • March 23, 2026

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