Addition of CAD polygenic risk score to coronary artery calcium score enhances prediction of MACE - Takeaways - MDSpire

Addition of CAD polygenic risk score to coronary artery calcium score enhances prediction of MACE

  • By

  • Andrii Maryniak

  • Filip Oleszak

  • Kevin Coy

  • Eric Larson

  • Catherine Hajek

  • Shubhi Bartaria

  • Shaopeng Gu

  • Max Weaver

  • Jerome I. Rotter

  • Xiuqing Guo

  • Jingyi Tan

  • Henry J. Lin

  • Adam Stys

  • Natalia Baran

  • Tomasz Stys

  • June 4, 2026

  • 0 min

Share

  • 1

    Coronary heart disease (CHD) is prevalent in the U.S., necessitating accurate risk prediction for effective primary prevention.

  • 2

    The study evaluated the predictive utility of coronary artery calcium scores (CACS) and polygenic risk scores (PRS) for major adverse cardiovascular events (MACE).

  • 3

    Both CACS and PRS were significantly associated with future MACE, showing comparable predictive capabilities when analyzed individually.

  • 4

    Combining CAD PRS with CACS significantly improved predictive accuracy for MACE, outperforming either modality used alone.

  • 5

    The findings highlight the importance of integrating CACS and CAD PRS in cardiovascular risk assessment and necessitate further research for validation.

Original Source(s)

Addition of CAD polygenic risk score to coronary artery calcium score enhances prediction of MACE

  • by Andrii Maryniak, Filip Oleszak, Kevin Coy, Eric Larson, Catherine Hajek, Shubhi Bartaria, Shaopeng Gu, Max Weaver, Jerome I. Rotter, Xiuqing Guo, Jingyi Tan, Henry J. Lin, Adam Stys, Natalia Baran, Tomasz Stys

  • June 4, 2026

Related Content

Tenecteplase Fails to Boost EVT Outcomes

Phase 3 stroke trial leaves open the possibility of clinically meaningful benefit or harm in selected late-window patients.

Retinal Ischemia as Stroke Warning

Retrospective study investigates links between acute ischemic ocular events and increased stroke risk

  • May 8, 2026

  • 3 min
Associations of clinical obesity with arterial stiffness and cerebral small vessel disease: a population-based study