Efficacy of Perampanel as a Monotherapy for Seizure Control During Awake Craniotomy in Glioma Patients

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Awake craniotomy (AC) allows for extensive glioma resection while minimizing neurological deficits through real-time mapping.
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Intraoperative seizures (IOS) during AC can lead to complications, including increased intracranial pressure and neurological deterioration.
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The study investigates the efficacy of perampanel (PER) as a monotherapy for preventing IOS during awake craniotomy in glioma patients.
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PER was administered at least 3 days prior to surgery, with a dose of 2 mg, and adjusted based on the patient's clinical condition.
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The findings aim to clarify the clinical utility of PER monotherapy in reducing intraoperative seizures compared to combination therapies.

Journal Of Neuro-Oncology (Springer)

by Yuta Koketsu, Shoichi Deguchi, Fumiharu Ohka, Kosuke Aoki, Yoshiki Shiba, Yuhei Takido, Shigeaki Nawa, Takehito Sato, Koichi Akiyama, Ryuta Saito
April 24, 2026

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