Human internal exposures to alternariol and its monomethyl ether are predicted below thresholds of in vitro toxicity by physiologically based kinetic modeling - Takeaways - MDSpire

Human internal exposures to alternariol and its monomethyl ether are predicted below thresholds of in vitro toxicity by physiologically based kinetic modeling

  • By

  • Eszter Borsos

  • Blandine Descamps

  • Nick Hetzschold

  • Elisabeth Varga

  • Doris Marko

  • Georg Aichinger

  • June 27, 2026

  • 0 min

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  • 1

    Alternariol (AOH) and alternariol monomethyl ether (AME) are emerging mycotoxins found in various food commodities.

  • 2

    The European Food Safety Authority has indicated that chronic dietary exposure to AOH and AME may exceed toxicological concern thresholds.

  • 3

    AOH and AME exhibit genotoxicity, oxidative stress induction, and potential endocrine-disrupting effects in vitro.

  • 4

    Physiologically based kinetic (PBK) modeling was developed to predict human tissue concentrations of AOH and AME after oral intake.

  • 5

    The study aims to provide a quantitative understanding of AOH and AME bioactivity as a preliminary step towards risk assessment.

Original Source(s)

Human internal exposures to alternariol and its monomethyl ether are predicted below thresholds of in vitro toxicity by physiologically based kinetic modeling

  • by Eszter Borsos, Blandine Descamps, Nick Hetzschold, Elisabeth Varga, Doris Marko, Georg Aichinger

  • June 27, 2026

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