Mental Health, Substance Use, and Tuberculosis Preventive Therapy in People With HIV: A Prospective Cohort Study - Takeaways - MDSpire

Mental Health, Substance Use, and Tuberculosis Preventive Therapy in People With HIV: A Prospective Cohort Study

  • By

  • Ann E Johnson

  • Lucy Chimoyi

  • Sheela Shenoi

  • Marie A Brault

  • Laura Forastiere

  • Salome Charalambous

  • Violet Chihota

  • J Lucian Davis

  • June 4, 2025

  • 0 min

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  • 1

    The study examined the impact of mental health and substance use on tuberculosis preventive therapy adherence among people with HIV in South Africa.

  • 2

    Among 224 participants, 50% completed tuberculosis preventive therapy, with high rates of depression (36%) and anxiety (28%) reported.

  • 3

    Depression symptoms were significantly associated with lower adherence and completion rates of tuberculosis preventive therapy.

  • 4

    The study highlighted the need for social and psychological support services to improve tuberculosis preventive therapy adherence.

  • 5

    Common mental health issues among participants included unhealthy alcohol use (34%) and tobacco use (27%), complicating tuberculosis preventive therapy efforts.

Original Source(s)

Mental Health, Substance Use, and Tuberculosis Preventive Therapy in People With HIV: A Prospective Cohort Study

  • by Ann E Johnson, Lucy Chimoyi, Sheela Shenoi, Marie A Brault, Laura Forastiere, Salome Charalambous, Violet Chihota, J Lucian Davis

  • June 4, 2025

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