GSK3βhigh/NFATc1high subtype targeting overcomes therapy resistance in pancreatic cancer through transcriptional induction of homologous recombination repair - Takeaways - MDSpire
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Targeting the GSK3βhigh/NFATc1high Subtype to Overcome Therapy Resistance in Pancreatic Cancer via Induction of Homologous Recombination Repair Mechanisms

  • By

  • Muhammad Umair Latif

  • Xueang Liu

  • Aiko Bockelmann

  • Laura Huhnold

  • Geske Elisabeth Schmidt

  • Lukas Klein

  • Xueyuan Zhao

  • Lena-Christin Conradi

  • Karly Conrads

  • Anna Lena Weber

  • Sercan Mercan

  • Kristina Reutlinger

  • Atmika Paul

  • Zeynab Najafova

  • Steven A Johnsen

  • Zuriñe Bonilla Del Rio

  • Frederike Penz

  • Jovan Todorovic

  • Holger Bastians

  • Tim Beissbarth

  • Ulrich Sax

  • Ramy Ashry

  • Oliver H Krämer

  • Elisabeth Hessmann

  • Günter Schneider

  • Philipp Stroebel

  • Ivan Bogeski

  • Shiv K Singh

  • Volker Ellenrieder

  • August 1, 2026

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  • 1

    The GSK3βhigh/NFATc1high subtype of pancreatic ductal adenocarcinoma (PDAC) is linked to aggressive tumor behavior and poor survival outcomes.

  • 2

    Nuclear GSK3β enhances tumor growth and DNA repair by activating NFATc1-dependent transcription of homologous recombination repair genes.

  • 3

    Inhibition of nuclear GSK3β-NFATc1 signaling can impair homologous recombination and improve the effectiveness of cisplatin in resistant PDAC.

  • 4

    The study highlights a correlation between the GSK3βhigh/NFATc1high subtype and rapid tumor recurrence in patients with resected PDAC.

  • 5

    Future research is needed to validate these findings and explore the potential of targeting the GSK3β-NFATc1 axis in clinical trials.

Original Source(s)

GSK3βhigh/NFATc1high subtype targeting overcomes therapy resistance in pancreatic cancer through transcriptional induction of homologous recombination repair

  • by Muhammad Umair Latif, Xueang Liu, Aiko Bockelmann, Laura Huhnold, Geske Elisabeth Schmidt, Lukas Klein, Xueyuan Zhao, Lena-Christin Conradi, Karly Conrads, Anna Lena Weber, Sercan Mercan, Kristina Reutlinger, Atmika Paul, Zeynab Najafova, Steven A Johnsen, Zuriñe Bonilla Del Rio, Frederike Penz, Jovan Todorovic, Holger Bastians, Tim Beissbarth, Ulrich Sax, Ramy Ashry, Oliver H Krämer, Elisabeth Hessmann, Günter Schneider, Philipp Stroebel, Ivan Bogeski, Shiv K Singh, Volker Ellenrieder

  • August 1, 2026

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