Weaning success and ventilation duration in PRiVENT: reply to Cheng - Takeaways - MDSpire
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PRiVENT: Response to Cheng on Weaning Outcomes and Duration of Mechanical Ventilation

  • By

  • Franziska C. Trudzinski

  • Teresa Byczkowski

  • Benjamin Neetz

  • Janina Schubert-Haack

  • Manuel Feißt

  • Joachim Szecsenyi

  • Felix J. F. Herth

  • November 13, 2026

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  • 1

    The primary endpoint classified patients who died before discharge as weaning failures, even if invasive ventilation had been discontinued temporarily.

  • 2

    PRiVENT enrolled patients at elevated risk for prolonged weaning and aimed to provide early access to specialized expertise.

  • 3

    Among ICU survivors, an exploratory analysis found higher odds of successful weaning with the intervention, but exclusion of deaths created potential selection bias.

  • 4

    Adjusted competing-risk analysis found no statistically significant association between the intervention and successful weaning (sHR, 1.12; 95% CI, 0.91-1.38; P = .30).

  • 5

    PRiVENT used a prospective, nonrandomized design to limit contamination across institutions, but this design retained limitations for causal inference.

Original Source(s)

Weaning success and ventilation duration in PRiVENT: reply to Cheng

  • by Franziska C. Trudzinski, Teresa Byczkowski, Benjamin Neetz, Janina Schubert-Haack, Manuel Feißt, Joachim Szecsenyi, Felix J. F. Herth

  • November 13, 2026

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