Impact of Previous HPV Infection and CD4 T-Cell Levels on Immune Responses to a Three-Dose Nonavalent HPV Vaccine in Individuals with HIV Undergoing ART - Takeaways - MDSpire

Impact of Previous HPV Infection and CD4 T-Cell Levels on Immune Responses to a Three-Dose Nonavalent HPV Vaccine in Individuals with HIV Undergoing ART

  • By

  • Eeva Tortellini

  • Mariasilvia Guardiani

  • Anna Carraro

  • Lorenzo Ansaldo

  • Sara Corazza

  • Sara Giovanna De Maria

  • Silvia Garattini

  • Mirko Barresi

  • Valeria Belvisi

  • Maria Antonella Zingaropoli

  • Federica Dominelli

  • Carmen Falvino

  • Fabio Mengoni

  • Alessandro Tavelli

  • Cristina Giambi

  • Claudio Maria Mastroianni

  • Cosmo Del Borgo

  • Raffaella Marocco

  • Miriam Lichtner

  • December 24, 2025

  • 0 min

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  • 1

    People with HIV have a higher incidence of HPV infection, increasing their risk for HPV-related cancers.

  • 2

    The nonavalent HPV vaccine Gardasil 9® is recommended for immunizing people with HIV, following a three-dose schedule.

  • 3

    Studies show that immune responses to HPV vaccines in people with HIV are comparable to those in HIV-uninfected individuals.

  • 4

    T-cell responses to the HPV vaccine are positively correlated with CD4 T-cell counts and negatively correlated with HIV plasma RNA load.

  • 5

    The study aims to evaluate the T-cell response to the Gardasil 9® vaccine, focusing on prior HPV infection and CD4 T-cell levels.

Original Source(s)

Impact of Previous HPV Infection and CD4 T-Cell Levels on Immune Responses to a Three-Dose Nonavalent HPV Vaccine in Individuals with HIV Undergoing ART

  • by Eeva Tortellini, Mariasilvia Guardiani, Anna Carraro, Lorenzo Ansaldo, Sara Corazza, Sara Giovanna De Maria, Silvia Garattini, Mirko Barresi, Valeria Belvisi, Maria Antonella Zingaropoli, Federica Dominelli, Carmen Falvino, Fabio Mengoni, Alessandro Tavelli, Cristina Giambi, Claudio Maria Mastroianni, Cosmo Del Borgo, Raffaella Marocco, Miriam Lichtner

  • December 24, 2025

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