Simultaneous quantification of perfusion, permeability, and leakage effects in brain gliomas using dynamic spin-and-gradient-echo echoplanar imaging MRI - Takeaways - MDSpire

Simultaneous quantification of perfusion, permeability, and leakage effects in brain gliomas using dynamic spin-and-gradient-echo echoplanar imaging MRI

  • By

  • Francesco Sanvito

  • Catalina Raymond

  • Nicholas S. Cho

  • Jingwen Yao

  • Akifumi Hagiwara

  • Joey Orpilla

  • Linda M. Liau

  • Richard G. Everson

  • Phioanh L. Nghiemphu

  • Albert Lai

  • Robert Prins

  • Noriko Salamon

  • Timothy F. Cloughesy

  • Benjamin M. Ellingson

  • October 26, 2023

  • 0 min

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  • 1

    Dual-echo DSC MRI can simultaneously quantify perfusion, permeability, and leakage effects in brain gliomas, enhancing diagnostic efficiency.

  • 2

    TRATE, a novel biomarker derived from dual-echo DSC, quantifies T2*-leakage effects and is independent of acquisition parameters.

  • 3

    The study aims to correlate TRATE with PSR and ΔR1,ss with Ktrans, linking these metrics to glioma cytoarchitecture and BBB permeability.

  • 4

    Increased TRATE is hypothesized to indicate aggressive tumor features, particularly in IDH wild-type glioblastomas with high Ki67 expression.

  • 5

    Dynamic SAGE-EPI allows for comprehensive imaging of gliomas, reducing the need for multiple contrast agent doses and scanning time.

Original Source(s)

Simultaneous quantification of perfusion, permeability, and leakage effects in brain gliomas using dynamic spin-and-gradient-echo echoplanar imaging MRI

  • by Francesco Sanvito, Catalina Raymond, Nicholas S. Cho, Jingwen Yao, Akifumi Hagiwara, Joey Orpilla, Linda M. Liau, Richard G. Everson, Phioanh L. Nghiemphu, Albert Lai, Robert Prins, Noriko Salamon, Timothy F. Cloughesy, Benjamin M. Ellingson

  • October 26, 2023

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