Damage-associated molecular patterns in hepatic ischemia–reperfusion injury: spatiotemporal signatures, biomarker potential, and clinical translation - Takeaways - MDSpire

Damage-associated molecular patterns in hepatic ischemia–reperfusion injury: spatiotemporal signatures, biomarker potential, and clinical translation

  • By

  • Peng An

  • Yi An

  • Mengwei Chen

  • Longlong Wu

  • Rong Wang

  • May 28, 2026

  • 0 min

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  • 1

    Hepatic ischemia-reperfusion injury (HIRI) significantly contributes to early allograft dysfunction and complications in liver transplantation.

  • 2

    Damage-associated molecular patterns (DAMPs) play a crucial role in mediating sterile inflammation during HIRI and have translational relevance.

  • 3

    DAMPs are released from various cellular sources during different phases of ischemia and reperfusion, influencing injury responses.

  • 4

    Circulating DAMP signatures can serve as minimally invasive biomarkers for injury grading and donor graft quality assessment.

  • 5

    DAMP-targeted therapeutic strategies aim to limit DAMP release and enhance clearance, with barriers to clinical translation needing to be addressed.

Original Source(s)

Damage-associated molecular patterns in hepatic ischemia–reperfusion injury: spatiotemporal signatures, biomarker potential, and clinical translation

  • by Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang

  • May 28, 2026

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