Longitudinal spatial changes of the contralesional corticospinal tract in high-grade glioma: a within-patient DTI tractography study - Takeaways - MDSpire
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Within-Patient DTI Tractography Reveals Longitudinal Spatial Changes in the Contralesional Corticospinal Tract in High-Grade Glioma

  • By

  • Bingzhen Li

  • Raimunde Liang

  • Ghaith Altawalbeh

  • Lisa Hoenikl

  • Eugen Ursu

  • Axel Schroeder

  • Haosu Zhang

  • Philipp Karschnia

  • Chiara Negwer

  • Bernhard Meyer

  • Arthur Wagner

  • October 9, 2026

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  • 1

    This retrospective, single-center study examined longitudinal contralesional corticospinal tract changes in 29 adults with frontal high-grade glioma and preserved motor strength.

  • 2

    Patients underwent preoperative diffusion tensor imaging before surgery for primary disease and first recurrence, and deterministic tractography reconstructed the contralesional motor component of the

  • 3

    The study compared tract-averaged fractional anisotropy, length, and volume, as well as spatial trajectory and voxel-level distribution after normalization to MNI152 space.

  • 4

    Primary and recurrent tract masks were harmonized to the negative MNI-X side, and longitudinal displacement was defined as recurrent minus primary.

  • 5

    The exploratory study prespecified no direction of change and investigated whether the contralesional tract varied between primary and recurrent disease.

Original Source(s)

Longitudinal spatial changes of the contralesional corticospinal tract in high-grade glioma: a within-patient DTI tractography study

  • by Bingzhen Li, Raimunde Liang, Ghaith Altawalbeh, Lisa Hoenikl, Eugen Ursu, Axel Schroeder, Haosu Zhang, Philipp Karschnia, Chiara Negwer, Bernhard Meyer, Arthur Wagner

  • October 9, 2026

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