Hemoglobin glycation index and short-term mortality in sepsis: a retrospective cohort study with external validation - Takeaways - MDSpire

Hemoglobin glycation index and short-term mortality in sepsis: a retrospective cohort study with external validation

  • By

  • Qianping Zhang

  • Yan Zhang

  • Xuemeng Li

  • Xinyi Tian

  • Zhijun Meng

  • Jin Zhang

  • Jie Weng

  • Kaifan Lin

  • Bihuan Cheng

  • Yuqiang Gong

  • Ye Gao

  • July 8, 2026

  • 0 min

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  • 1

    The study analyzed the association between hemoglobin glycation index (HGI) and short-term mortality in sepsis using a retrospective cohort from the MIMIC-IV database.

  • 2

    In the primary cohort of 2,073 patients, lower HGI levels were significantly associated with higher 28-day mortality rates among non-survivors.

  • 3

    Patients in the highest HGI quartile had a significantly lower risk of 28-day mortality compared to those in the lowest quartile, with a hazard ratio of 0.70.

  • 4

    The findings were validated in an external cohort of 166 patients, where higher HGI was similarly linked to reduced 28-day mortality.

  • 5

    The study suggests that HGI may provide prognostic information during the early phase of sepsis, warranting further prospective studies.

Original Source(s)

Hemoglobin glycation index and short-term mortality in sepsis: a retrospective cohort study with external validation

  • by Qianping Zhang, Yan Zhang, Xuemeng Li, Xinyi Tian, Zhijun Meng, Jin Zhang, Jie Weng, Kaifan Lin, Bihuan Cheng, Yuqiang Gong, Ye Gao

  • July 8, 2026

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