PFO closure in ischemic stroke: insights from a single-center real-world cohort - Takeaways - MDSpire

PFO closure in ischemic stroke: insights from a single-center real-world cohort

  • By

  • Felix Müller

  • Arda Civelek

  • Luis Weitbrecht

  • Lukas Badura

  • Kai Helge Schmidt

  • Florian Schlotter

  • Philipp Lurz

  • Stavros V. Konstantinides

  • Karsten Keller

  • Klaus Gröschel

  • Marianne Hahn

  • Timo Uphaus

  • May 8, 2026

  • 0 min

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  • 1

    The study investigates real-world management of ischemic stroke patients with PFO at a single center from 2015 to 2022.

  • 2

    Among 188 patients, 62 underwent PFO closure, showing younger age and fewer cardiovascular risk factors compared to those who did not.

  • 3

    The RoPE score was significantly higher in the closure group, indicating a stronger association between PFO and stroke.

  • 4

    The AS5F score was lower in closure patients but higher in those with atrial fibrillation, suggesting a link between age, stroke severity, and AF risk.

  • 5

    The findings highlight the need for comprehensive risk evaluation in PFO-related strokes, particularly in older patients with recurrent events.

Original Source(s)

PFO closure in ischemic stroke: insights from a single-center real-world cohort

  • by Felix Müller, Arda Civelek, Luis Weitbrecht, Lukas Badura, Kai Helge Schmidt, Florian Schlotter, Philipp Lurz, Stavros V. Konstantinides, Karsten Keller, Klaus Gröschel, Marianne Hahn, Timo Uphaus

  • May 8, 2026

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