Cutting out the unnecessary: deprescribing antihypertensive treatments in patients at low cardiovascular risk - Takeaways - MDSpire

Cutting out the unnecessary: deprescribing antihypertensive treatments in patients at low cardiovascular risk

  • By

  • Matteo Lemoli

  • Claudia Agabiti Rosei

  • Maria Lorenza Muiesan

  • February 10, 2026

  • 0 min

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  • 1

    The STOP trial assessed antihypertensive treatment discontinuation in patients with low cardiovascular risk and Grade 1 hypertension.

  • 2

    After one year, 36% of participants maintained normotension after stopping antihypertensive therapy, while 64% required treatment restart.

  • 3

    Initial home blood pressure readings below 120/80 mmHg were associated with a higher likelihood of maintaining normotension.

  • 4

    The study highlights the importance of out-of-office blood pressure monitoring and repeated measurements for accurate hypertension diagnosis.

  • 5

    Angiotensin-receptor blocker use was positively correlated with normotension persistence after antihypertensive treatment withdrawal.

Original Source(s)

Cutting out the unnecessary: deprescribing antihypertensive treatments in patients at low cardiovascular risk

  • by Matteo Lemoli, Claudia Agabiti Rosei, Maria Lorenza Muiesan

  • February 10, 2026

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