Integrative multi-omics profiling reveals coordinated immunometabolic reprogramming and host-microbiome interactions in acute pancreatitis - Takeaways - MDSpire

Integrative multi-omics profiling reveals coordinated immunometabolic reprogramming and host-microbiome interactions in acute pancreatitis

  • By

  • Peng Dai

  • Jing Feng

  • Jianghong Cao

  • Daguang Fan

  • June 19, 2026

  • 0 min

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  • 1

    Acute pancreatitis (AP) is a severe inflammatory disorder with rising global incidence and high mortality rates in severe cases.

  • 2

    The study utilized multi-omics analysis to investigate immune, metabolic, and microbiome interactions in 15 AP patients and 15 healthy controls.

  • 3

    Transcriptomic profiling revealed 4,776 differentially expressed genes, with significant enrichment in inflammatory pathways like NF-κB and IL-17.

  • 4

    Metabolomic analysis identified 296 differentially expressed metabolites, with notable changes in amino acid and lipid metabolism.

  • 5

    The integration of multi-omics data revealed 215 significant correlations, highlighting potential biomarkers for further validation in larger cohorts.

Original Source(s)

Integrative multi-omics profiling reveals coordinated immunometabolic reprogramming and host-microbiome interactions in acute pancreatitis

  • by Peng Dai, Jing Feng, Jianghong Cao, Daguang Fan

  • June 19, 2026

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