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1
Acute pancreatitis (AP) is a severe inflammatory disorder with rising global incidence and high mortality rates in severe cases.
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The study utilized multi-omics analysis to investigate immune, metabolic, and microbiome interactions in 15 AP patients and 15 healthy controls.
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3
Transcriptomic profiling revealed 4,776 differentially expressed genes, with significant enrichment in inflammatory pathways like NF-κB and IL-17.
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Metabolomic analysis identified 296 differentially expressed metabolites, with notable changes in amino acid and lipid metabolism.
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The integration of multi-omics data revealed 215 significant correlations, highlighting potential biomarkers for further validation in larger cohorts.
