Distal and local mucosal immunization with a BoHV-4-based vector delivering CpHV-1 gD confers protection against intravaginal CpHV-1 challenge in goats - Takeaways - MDSpire

Distal and local mucosal immunization with a BoHV-4-based vector delivering CpHV-1 gD confers protection against intravaginal CpHV-1 challenge in goats

  • By

  • Amienwanlen Eugene Odigie

  • Sergio Minesso

  • Valentina Franceschi

  • Grazia Greco

  • Vittorio Madia

  • Michele Camero

  • Maria Tempesta

  • Gaetano Donofrio

  • July 14, 2026

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  • 1

    Mucosal vaccination using a BoHV-4 vector expressing CpHV-1 gD protects goats from intravaginal CpHV-1 infection.

  • 2

    Both intravaginal and intranasal immunization routes provided complete protection against CpHV-1 disease in vaccinated goats.

  • 3

    Vaccinated goats exhibited no fever or genital pathology post-challenge, contrasting with unvaccinated controls.

  • 4

    Intravaginal immunization resulted in superior control of genital virus excretion compared to intranasal vaccination.

  • 5

    The study establishes the goat-CpHV-1 model as a valuable system for preclinical evaluation of mucosal herpesvirus vaccines.

Original Source(s)

Distal and local mucosal immunization with a BoHV-4-based vector delivering CpHV-1 gD confers protection against intravaginal CpHV-1 challenge in goats

  • by Amienwanlen Eugene Odigie, Sergio Minesso, Valentina Franceschi, Grazia Greco, Vittorio Madia, Michele Camero, Maria Tempesta, Gaetano Donofrio

  • July 14, 2026

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