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Organ Damage, BMI Linked to Fatigue in SLE

Cross-sectional study suggests fatigue is associated with damage accrual and body mass, not disease activity

  • By

  • Andrea Surnit

  • April 20, 2026

  • 3 min

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  • 1

    Clinically significant fatigue in systemic lupus erythematosus is linked to greater organ damage and higher body mass index.

  • 2

    The study involved 183 patients, with 52% reporting clinically significant fatigue measured by the Fatigue Severity Scale.

  • 3

    Fatigue was not associated with disease activity, as patients had low mean SELENA-SLEDAI scores.

  • 4

    Racial differences were noted, with non-Hispanic White patients more likely to report significant fatigue than Black patients.

  • 5

    Pulmonary fibrosis and neuropathy were independently associated with fatigue severity, highlighting the need for further research.

Original Source(s)

Organ Damage, BMI Linked to Fatigue in SLE

  • by Andrea Surnit

  • April 20, 2026

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