Focused ultrasound-mediated enhancement of blood–brain barrier permeability for brain tumor treatment: a systematic review of clinical trials - Takeaways - MDSpire

Focused ultrasound-mediated enhancement of blood–brain barrier permeability for brain tumor treatment: a systematic review of clinical trials

  • By

  • Honglin Zhu

  • Caitlin Allwin

  • Monica G. Bassous

  • Antonios N. Pouliopoulos

  • August 29, 2024

  • 0 min

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  • 1

    Brain tumors, especially glioblastoma multiforme, have a poor prognosis, with less than 20% of patients surviving beyond 5 years post-diagnosis.

  • 2

    The blood-brain barrier (BBB) poses significant challenges for drug delivery in brain tumors, limiting therapeutic efficacy.

  • 3

    Focused ultrasound (FUS) is a promising non-invasive technique that can transiently open the BBB, enhancing drug delivery to brain tumors.

  • 4

    Pre-clinical studies have shown that FUS-mediated BBB opening is safe and effective, leading to human clinical trials for brain tumor treatment.

  • 5

    Current clinical trials primarily focus on the safety and feasibility of FUS for enhancing drug delivery in recurrent glioblastoma and other gliomas.

Original Source(s)

Focused ultrasound-mediated enhancement of blood–brain barrier permeability for brain tumor treatment: a systematic review of clinical trials

  • by Honglin Zhu, Caitlin Allwin, Monica G. Bassous, Antonios N. Pouliopoulos

  • August 29, 2024

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