Oral microbiota alterations in radiographic axial spondyloarthritis

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Patients with radiographic axial spondyloarthritis exhibit significant alterations in their oral microbiome compared to healthy controls.
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Key microbial taxa such as Actinobacteria and Spirochaetes are enriched in r-axSpA patients, particularly Actinomyces and Selenomonas.
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Increased abundance of periodontal pathogens like Porphyromonas gingivalis correlates with disease severity in r-axSpA patients.
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Oral dysbiosis in r-axSpA patients is linked to elevated systemic pro-inflammatory cytokines, suggesting a role in inflammation.
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The findings indicate that the oral microbiome may serve as a potential source of biomarkers or therapeutic targets in r-axSpA.

Frontiers In Medicine

by Aigerim Abuova, Assel Meiramova, Yekaterina Zueva, Jeannette Kunz, Laura Chulenbayeva, Argul Issilbayeva, Zharkyn Jarmukhanov, Elizaveta Vinogradova, Bayan Ainabekova, Samat Kozhakhmetov, Almagul Kushugulova
May 12, 2026

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