Identification of genes differentially expressed in granulosa cells from women with high vs. low ovarian responsiveness - Takeaways - MDSpire

Identification of genes differentially expressed in granulosa cells from women with high vs. low ovarian responsiveness

  • By

  • Alexa Medica

  • Matthew E. Kim

  • Wei-Ting Hung

  • Abhishek Sohni

  • Antoni Duleba

  • Kun Tan

  • Miles F. Wilkinson

  • June 10, 2026

  • 0 min

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  • 1

    RNA sequencing identified 291 genes downregulated in granulosa cells from poor ovarian responders compared to normal responders.

  • 2

    Downregulated genes in poor responders are linked to pro-proliferation functions and DNA damage-response mechanisms.

  • 3

    Upregulated genes in poor responders include those associated with apoptosis and ovarian malignancy.

  • 4

    Weighted gene co-expression analysis revealed six gene modules correlated with the poor ovarian response phenotype.

  • 5

    The study provides insights into potential pathways to improve IVF outcomes for women with weak ovarian responses.

Original Source(s)

Identification of genes differentially expressed in granulosa cells from women with high vs. low ovarian responsiveness

  • by Alexa Medica, Matthew E. Kim, Wei-Ting Hung, Abhishek Sohni, Antoni Duleba, Kun Tan, Miles F. Wilkinson

  • June 10, 2026

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