Oral and gut microbiota dysbiosis with strengthened oral–gut connectivity in post-stroke cognitive impairment - Takeaways - MDSpire

Oral and gut microbiota dysbiosis with strengthened oral–gut connectivity in post-stroke cognitive impairment

  • By

  • Xuetong Zhang

  • Fanping Chen

  • Jie Yang

  • Jiang Ma

  • Xiaoyan Li

  • Hui Wang

  • Qing Li

  • Yubin Zhao

  • Jianchao Xu

  • June 4, 2026

  • 0 min

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  • 1

    Post-stroke cognitive impairment (PSCI) is linked to coordinated dysbiosis in both oral and gut microbiota.

  • 2

    PSCI participants exhibited reduced oral richness and gut diversity, with significant differences in microbial composition.

  • 3

    Oral commensals were depleted while opportunistic taxa increased in PSCI, indicating a shift in microbial balance.

  • 4

    The study introduced an oral enrichment score (OES) to measure gut 'oralization', showing stronger oral-gut associations in PSCI.

  • 5

    Findings suggest potential functional alterations in gut microbiota related to lipopolysaccharide biosynthesis and tryptophan metabolism.

Original Source(s)

Oral and gut microbiota dysbiosis with strengthened oral–gut connectivity in post-stroke cognitive impairment

  • by Xuetong Zhang, Fanping Chen, Jie Yang, Jiang Ma, Xiaoyan Li, Hui Wang, Qing Li, Yubin Zhao, Jianchao Xu

  • June 4, 2026

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