Case Report: Recurrent gestation-limited intractable abdominal colic with elevated phthalate and paraben biomarkers: a hypothesis-generating observation - Takeaways - MDSpire

Case Report: Recurrent gestation-limited intractable abdominal colic with elevated phthalate and paraben biomarkers: a hypothesis-generating observation

  • By

  • Suling Sun

  • Yadan Zou

  • Xiangyuan Liu

  • Sheng-Guang Li

  • July 13, 2026

Share

  • 1

    A 35-year-old woman experienced recurrent severe abdominal colic during five pregnancies, leading to four terminations due to intractable symptoms.

  • 2

    Elevated biomarkers of monoethyl phthalate, methylparaben, and propylparaben were detected in urine, exceeding laboratory reference limits.

  • 3

    A multidomain preconception program aimed to reduce EDC exposure and address metabolic, immune, nutritional, and gut dysbiosis factors.

  • 4

    After intervention, urine testing showed biomarker levels below laboratory limits, and the patient had a successful pregnancy without recurrent colic.

  • 5

    The case highlights the need for targeted exposure history and selective biomonitoring in patients with unexplained pregnancy-specific morbidity.

Original Source(s)

Case Report: Recurrent gestation-limited intractable abdominal colic with elevated phthalate and paraben biomarkers: a hypothesis-generating observation

  • by Suling Sun, Yadan Zou, Xiangyuan Liu, Sheng-Guang Li

  • July 13, 2026

Related Content

Twenty-five-year trends in mortality and major morbidity among very low birth weight infants at a Saudi tertiary centre: improving morbidity despite expanding resuscitation at the limits of viability

Correction: Nutrition and diet myths, knowledge and practice during pregnancy and lactation among a sample of Egyptian pregnant women: a cross-sectional study

Molecular classification and immunotherapy in fertility-sparing treatment for endometrial cancer: opportunities and challenges