Intraoperative radiotherapy after resection of newly diagnosed brain metastases in adult patients - results of a prospective phase II trial (INTRAMET) - Takeaways - MDSpire
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Prospective Phase II Trial Results of Intraoperative Radiotherapy Following Resection of Newly Diagnosed Brain Metastases in Adult Patients (INTRAMET)

  • By

  • Stefanie Brehmer

  • Gustavo R. Sarria

  • Sara Würfel

  • Ardita Sulejmani

  • Frank Schneider

  • Sven Clausen

  • Yasser Abo-Madyan

  • Arne M. Ruder

  • Elena Sperk

  • Nima Etminan

  • Frank A. Giordano

  • May 28, 2026

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  • 1

    Brain metastases occur in approximately 20% of cancer patients, with survival typically measured in months due to advanced systemic disease.

  • 2

    Intraoperative radiotherapy (IORT) delivers adjuvant treatment immediately after tumor resection, potentially improving local control rates.

  • 3

    The INTRAMET trial evaluated the efficacy and safety of kilovoltage IORT in patients with newly diagnosed brain metastases.

  • 4

    The study aimed to enroll 50 patients, targeting local control rates comparable to those of adjuvant stereotactic radiosurgery.

  • 5

    Primary endpoint was local control rate, defined as absence of in-cavity or marginal lesions suggestive of recurrence on MRI.

Original Source(s)

Intraoperative radiotherapy after resection of newly diagnosed brain metastases in adult patients - results of a prospective phase II trial (INTRAMET)

  • by Stefanie Brehmer, Gustavo R. Sarria, Sara Würfel, Ardita Sulejmani, Frank Schneider, Sven Clausen, Yasser Abo-Madyan, Arne M. Ruder, Elena Sperk, Nima Etminan, Frank A. Giordano

  • May 28, 2026

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