Faecal inflammatory protein markers in children with autism spectrum disorder are comparable to their healthy siblings - Takeaways - MDSpire

Faecal inflammatory protein markers in children with autism spectrum disorder are comparable to their healthy siblings

  • By

  • Joško Osredkar

  • Petra Finderle

  • Uroš Godnov

  • Maja Jekovec-Vrhovšek

  • Veronika Vidova

  • James Price Elliott

  • Teja Fabjan

  • Gorazd Avguštin

  • Damjan Osredkar

  • Kristina Kumer

  • April 15, 2026

  • 0 min

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  • 1

    The study compared fecal inflammatory protein levels in 57 children with autism spectrum disorder (ASD) and their 57 healthy siblings.

  • 2

    Children with ASD exhibited trends of higher immunoglobulin A (IgA) and calprotectin, and lower α1-antitrypsin (A1AT), though differences were not statistically significant.

  • 3

    Subgroup analysis indicated different patterns of protein levels in moderate versus severe ASD, suggesting potential variability in gut inflammation.

  • 4

    The findings align with meta-analyses indicating no consistent evidence of gut inflammation in ASD, highlighting the need for larger studies.

  • 5

    Further research is necessary to validate the role of stool proteins as biomarkers for ASD, particularly in adequately powered studies.

Original Source(s)

Faecal inflammatory protein markers in children with autism spectrum disorder are comparable to their healthy siblings

  • by Joško Osredkar, Petra Finderle, Uroš Godnov, Maja Jekovec-Vrhovšek, Veronika Vidova, James Price Elliott, Teja Fabjan, Gorazd Avguštin, Damjan Osredkar, Kristina Kumer

  • April 15, 2026

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