AI-driven insights into protein misfolding and innate immunity in neurodegenerative diseases

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Neurodegenerative diseases are characterized by protein misfolding and chronic neuroinflammation, affecting both adults and children.
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Misfolded proteins like β-amyloid, Tau, and α-synuclein trigger neuroinflammatory responses by acting as damage-associated molecular patterns.
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Artificial intelligence has advanced protein structure prediction and modeling, revealing connections between protein misfolding and innate immunity.
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Deep learning models such as AlphaFold and I-TASSER enhance understanding of neurodegenerative disease mechanisms and potential diagnostics.
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AI tools offer innovative approaches for diagnosing and treating pediatric neurodegenerative disorders, addressing unique challenges in this field.

Frontiers In Immunology

by Hui Xin Deng, Jing Ling Cao, Yao Wu, Si Jin Jiang, Qian Qian Fang, Bi Yue Zhu, Yong Jian Jiang
May 12, 2026

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