Functional ultrasound assessment of cerebral blood flow and brain connectivity in a pilocarpine-induced acute epileptic seizures in mice

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Temporal lobe epilepsy (TLE) is a prevalent form of epilepsy with no effective curative treatments currently available.
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Functional ultrasound imaging (fUS) was utilized to assess changes in cerebral blood volume (CBV) during acute seizure states in mice.
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Most brain regions showed changes in relative CBV, with all but two regions exhibiting an initial increase followed by a decrease.
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The reticular nucleus of the thalamus (RT) exhibited earlier changes in rCBV compared to other brain regions.
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Overall brain functional network connectivity underwent significant modifications during the acute seizure state in TLE mice.

Frontiers In Neurology

by Yao Liu, Chang Xu, Wenqian Ma, Dan Zhao, Baocong Yu, Rui Zhang, Haiyue Huang, Jianguo Niu, Ling He, Yujun Wen
June 15, 2026

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