Integrative analysis of GEO data on the microbial community in colorectal cancer tissues and its impact on the tumor immune microenvironment

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Colorectal cancer development is linked to gut microbiota dysbiosis and alterations in the tumor immune microenvironment.
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The study identified seven key bacterial genera with altered abundances in CRC, including pathogenic and beneficial species.
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CRC patients showed reduced α diversity and significant changes in immune cell proportions, particularly a decrease in B-cell infiltration.
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Cross-dataset analysis revealed associations between pathogenic bacteria and myeloid cells, while beneficial bacteria correlated with B-cells.
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The independent validation confirmed consistent abundance changes in six out of seven core bacterial genera across cohorts.

Frontiers In Oncology

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