Therapeutic Interaction Features of AI Chatbots in Depression Interventions: Systematic Review and Meta-Analysis - Takeaways - MDSpire

Therapeutic Interaction Features of AI Chatbots in Depression Interventions: Systematic Review and Meta-Analysis

  • By

  • Ting Huang

  • Shuangyu Li

  • Yanzhong Wang

  • Wei Liu

  • June 30, 2026

  • 0 min

Share

  • 1

    Depression affects over 280 million people globally, with a prevalence of 3.8% in the general population and 5.7% among adults aged 60 and older.

  • 2

    Digital mental health interventions (DMHIs) have emerged as scalable alternatives to traditional therapies, addressing barriers like workforce shortages and stigma.

  • 3

    AI-driven chatbots provide ongoing conversational support, distinguishing them from earlier DMHIs that relied on fixed content and limited interactivity.

  • 4

    A meta-analysis indicated that DMHIs can achieve clinical outcomes comparable to traditional therapies for mild to moderate depression.

  • 5

    AI chatbots are characterized by their capacity for sustained, multiturn dialogue, which is essential for therapeutic effectiveness and user engagement.

Original Source(s)

Therapeutic Interaction Features of AI Chatbots in Depression Interventions: Systematic Review and Meta-Analysis

  • by Ting Huang, Shuangyu Li, Yanzhong Wang, Wei Liu

  • June 30, 2026

Related Content

Dietary Inflammatory Index and Depressive Symptoms in Chinese University Students Leveraging an Intelligent Ordering System: 3-Year Longitudinal Prospective Cohort Study

Top 10 Physician Recruitment Trends

From signing bonuses and loan repayment programs to workforce initiatives and physician support resources, these trends reflect some of the strategies organizations are using to recruit and retain physicians in a competitive health care labor market.

The relationship between mobile phone addiction and depression, anxiety among Chinese college students: the mediating role of friendship quality and the moderating effect of preference for solitude