Gender-specific effects of vitamin D and B9 levels on neuroticism: a study utilizing polygenic scoring - Takeaways - MDSpire

Gender-specific effects of vitamin D and B9 levels on neuroticism: a study utilizing polygenic scoring

  • By

  • Margarita Alfimova

  • Vera Golimbet

  • Ekaterina Semina

  • Yulia Chaika

  • April 24, 2026

  • 0 min

Share

  • 1

    The study examines the relationship between neuroticism and vitamin D (VD) and vitamin B9 (VB9) levels using polygenic scores in a nonclinical cohort.

  • 2

    Results indicate a negative association between VB9-PGS and neuroticism scores in women, while men showed a positive association with VD-PGS.

  • 3

    Men with high VD-PGS also scored high on neuroticism and extraversion, suggesting a unique relationship between vitamin D and emotional traits.

  • 4

    Neuroticism scores in men were linked to genetic predispositions for bipolar disorder and alcohol use, differing from women's associations.

  • 5

    The findings highlight gender-specific effects of vitamin D and B9 on neuroticism, emphasizing the importance of these vitamins for emotional stability.

Original Source(s)

Gender-specific effects of vitamin D and B9 levels on neuroticism: a study utilizing polygenic scoring

  • by Margarita Alfimova, Vera Golimbet, Ekaterina Semina, Yulia Chaika

  • April 24, 2026

Related Content

Identifying psychiatric comorbidities that occur following the introduction of hormonal contraception: a scoping review

Virtual Exposure With Response Prevention for Obsessive-Compulsive Disorder: Randomized Controlled Trial

Cognition Associated With Future Depression Risk

Lower cognition is associated with later depression in controls, while higher cognition is associated with relapse in remitted depression