The Impact of Pediatric RSV Co-Infections in the Post-COVID-19 Era: An Overview of Epidemiological Trends and Clinical Significance

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The COVID-19 pandemic disrupted RSV epidemiology, leading to atypical off-season surges and increased co-infection rates in pediatric populations.
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RSV co-infections are common, with human rhinovirus being the most frequent viral co-pathogen and Streptococcus pneumoniae as a significant bacterial co-infection.
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Co-infections are associated with increased disease severity, longer hospital stays, and higher rates of ICU admissions among affected children.
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Post-pandemic, the incidence of RSV infections and co-infections has surged, revealing a susceptible pediatric population due to 'immunity debt'.
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Enhanced surveillance and equitable access to prevention strategies are essential to mitigate the burden of pediatric RSV co-infections in the post-COVID era.

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