Clinical characteristics and survival outcomes of TFE3-rearranged renal cell carcinoma: a retrospective study compared with clear cell renal cell carcinoma using propensity score matching

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TFE3-rearranged renal cell carcinoma (TFE3-rRCC) is a rare subtype of RCC, accounting for 1-4% of adult cases and 20-50% of pediatric cases.
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Diagnosis of TFE3-rRCC is challenging due to heterogeneous morphology and overlapping immunophenotype with other RCC subtypes.
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FISH testing is the most sensitive method for confirming TFE3 rearrangements, while TFE3 immunohistochemistry has limited specificity.
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The clinical behavior of TFE3-rRCC varies, with some studies reporting aggressive behavior and others showing outcomes similar to clear-cell RCC.
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This study utilized propensity score matching to compare survival outcomes between TFE3-rRCC and clear-cell RCC in a large cohort.

World Journal Of Urology

by Wencong Han, Kun Peng, Qi Shen, Shiwei Chen, Zejin Ou, Tai Kang, Xiaojun Yu, Jianbin Zhang, Zheng Zhang
October 31, 2025

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