Clinical characteristics and survival outcomes of TFE3-rearranged renal cell carcinoma: a retrospective study compared with clear cell renal cell carcinoma using propensity score matching - Takeaways - MDSpire
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Clinical Features and Survival Rates of TFE3-Rearranged Renal Cell Carcinoma: A Retrospective Analysis Compared to Clear Cell Renal Cell Carcinoma Using Propensity Score Matching

  • By

  • Wencong Han

  • Kun Peng

  • Qi Shen

  • Shiwei Chen

  • Zejin Ou

  • Tai Kang

  • Xiaojun Yu

  • Jianbin Zhang

  • Zheng Zhang

  • October 31, 2025

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  • 1

    TFE3-rearranged renal cell carcinoma (TFE3-rRCC) is a rare subtype of RCC, accounting for 1-4% of adult cases and 20-50% of pediatric cases.

  • 2

    Diagnosis of TFE3-rRCC is challenging due to heterogeneous morphology and overlapping immunophenotype with other RCC subtypes.

  • 3

    FISH testing is the most sensitive method for confirming TFE3 rearrangements, while TFE3 immunohistochemistry has limited specificity.

  • 4

    The clinical behavior of TFE3-rRCC varies, with some studies reporting aggressive behavior and others showing outcomes similar to clear-cell RCC.

  • 5

    This study utilized propensity score matching to compare survival outcomes between TFE3-rRCC and clear-cell RCC in a large cohort.

Original Source(s)

Clinical characteristics and survival outcomes of TFE3-rearranged renal cell carcinoma: a retrospective study compared with clear cell renal cell carcinoma using propensity score matching

  • by Wencong Han, Kun Peng, Qi Shen, Shiwei Chen, Zejin Ou, Tai Kang, Xiaojun Yu, Jianbin Zhang, Zheng Zhang

  • October 31, 2025

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