HCV Core Antigen Diagnostic Performance for Acute/Recent HCV Infection in People With HIV-1: A Systematic Review and Meta-Analysis - Takeaways - MDSpire

HCV Core Antigen Diagnostic Performance for Acute/Recent HCV Infection in People With HIV-1: A Systematic Review and Meta-Analysis

  • By

  • Tsung-Yu Tsai

  • Guan-Jhou Chen

  • Hsin-Yun Sun

  • Chien-Ching Hung

  • October 17, 2025

  • 0 min

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  • 1

    HCV core antigen (HCVcAg) effectively identifies acute HCV infection in people with HIV-1, showing high sensitivity and specificity.

  • 2

    The systematic review included four studies with 1015 participants, demonstrating a pooled sensitivity of 92% and specificity of 99% for HCVcAg.

  • 3

    HCVcAg's positive predictive value is 44%, while its negative predictive value is 100%, indicating its reliability in diagnosing acute HCV.

  • 4

    The study highlights the importance of early detection of acute HCV infection in PWH to prevent transmission and facilitate timely treatment.

  • 5

    Integrating HCVcAg into screening protocols for PWH could enhance HCV elimination efforts, particularly in resource-limited settings.

Original Source(s)

HCV Core Antigen Diagnostic Performance for Acute/Recent HCV Infection in People With HIV-1: A Systematic Review and Meta-Analysis

  • by Tsung-Yu Tsai, Guan-Jhou Chen, Hsin-Yun Sun, Chien-Ching Hung

  • October 17, 2025

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