Metaplastic breast carcinoma with osteosarcomatous differentiation: a case report - Takeaways - MDSpire

Metaplastic breast carcinoma with osteosarcomatous differentiation: a case report

  • By

  • Xiang Zhao

  • XiaoYu Sun

  • Jiaqi Liu

  • June 30, 2026

  • 0 min

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  • 1

    Metaplastic breast carcinoma (MBC) is a rare and aggressive cancer subtype, comprising less than 1% of all breast cancers.

  • 2

    MBC with osteosarcomatous differentiation is extremely rare, accounting for 0.003%-0.12% of breast cancer cases.

  • 3

    The case study involves a 65-year-old female with recurrent left breast mass diagnosed as triple-negative MBC with osteosarcomatous differentiation.

  • 4

    The patient underwent multimodal treatment including chemotherapy, immunotherapy, and modified radical mastectomy.

  • 5

    Postoperative pathology confirmed MBC with negative BRCA1/2 testing and all margins negative for metastasis.

Original Source(s)

Metaplastic breast carcinoma with osteosarcomatous differentiation: a case report

  • by Xiang Zhao, XiaoYu Sun, Jiaqi Liu

  • June 30, 2026

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