19 Gelatin-functionalised hyaluronic acid-based hydrogels with antimicrobial peptides for chronic wound treatment - Takeaways - MDSpire

19 Gelatin-functionalised hyaluronic acid-based hydrogels with antimicrobial peptides for chronic wound treatment

  • By

  • N Petit

  • Ana Gomes

  • Paula Gomes

  • S Browne

  • August 20, 2025

  • 0 min

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  • 1

    Chronic wounds, such as diabetic foot ulcers, result from impaired healing due to chronic hyperglycemia and increased infection risk.

  • 2

    A multifunctional hyaluronic acid-based hydrogel was developed to enhance cellular adhesion and provide localized antimicrobial activity.

  • 3

    The hydrogel was modified with acrylate groups and crosslinked with polyethylene glycol, improving stability and degradation profile.

  • 4

    Incorporating gelatin and antimicrobial peptides into the hydrogel significantly enhanced cell adhesion and provided bactericidal activity against Staphylococcus aureus.

  • 5

    The study suggests that these hydrogels have potential as multifunctional wound dressings for chronic wounds, warranting further pre-clinical evaluation.

Original Source(s)

19 Gelatin-functionalised hyaluronic acid-based hydrogels with antimicrobial peptides for chronic wound treatment

  • by N Petit, Ana Gomes, Paula Gomes, S Browne

  • August 20, 2025

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